Wellcome Sanger Institute

The world’s largest freely available cell map of the human gut has been created, combining spatial and single-cell data from 1.6 million cells. 🧬 This has revealed a new role that certain stomach cells may play in inflammatory bowel disease. 👀 By having a more complete picture of the human gut, researchers will be able to identify key changes or differences that may be involved in common gut conditions, such as ulcerative colitis and Crohn’s disease. This could lead to new possible targets for drug development.🔎 This paper is one of a collection of over 40 Human Cell Atlas publications in Nature Portfolio journals that are progressing our understanding of the human body. The Gut Cell Atlas is freely available for use and has been developed to allow future studies to be incorporated, creating an evolving resource for researchers around the world. Find out more below ⤵️ https://lnkd.in/eJFnwknA

Large-scale genetic analysis has uncovered new insight into how common DNA differences play a role in the development of rare brain conditions. In the future, these findings may help families and doctors to better understand, diagnose, and manage these conditions. 🔎 This research looked at rare neurodevelopmental conditions, those seen in less than one per cent of people, that affect the growth and development of the brain in childhood. In about half of people with these conditions, the cause is a single, rare DNA change. However, in some cases, the cause could be a complex interplay between different types of genetic and environmental factors. 🧬 While the team found that common DNA differences only play a small role, this study provides a more informed view of how these changes work together to cause rare brain conditions. This study used a combined dataset of over 40,000 people based in the UK, and the team are extremely grateful to the families for their participation and engagement as without them, this research would not have been possible. Read the full story ⬇ https://lnkd.in/edajjDmj

The first ‘blueprint’ of the developing human skeleton has revealed how bones and joints form, uncovering new insights that could help diagnose and treat skeletal conditions, such as osteoarthritis, in the future. 🔎 By using cutting-edge genomic techniques, the team from the Wellcome Sanger Institute and collaborators were able to ⬇️ • Show how cartilage acts as a scaffold for bone development across the skeleton, apart from the top of the skull. • Investigate how genetic changes in certain cells may cause soft spots in the skulls of newborns to fuse too early, restricting the growth of the developing brain. • Uncover that certain genetic changes in early bone cells or early cartilage cells could be linked to an increased risk of developing either hip or knee arthritis as an adult, depending on which cells were affected. • Highlight where 65 drugs may disrupt skeletal development. By mapping the cells and pathways involved in the developing skeleton, this research could help uncover new ways to diagnose and treat bone and joint conditions in the future. 💊 Read more, here ⤵️ https://lnkd.in/e9TyaHSH 📸 A 3D digital reconstruction of a developing cranium, where the cartilage is blue and the bone is shown in purple. Credit: A.Chédotal & R. Blain, Institut de la Vision, Paris & MeLiS/UCBL/ HCL, Lyon

It’s great to see that the Human Cell Atlas Collection of papers in Nature Portfolio and associated journals is now live! 🎉   Including research from teams at the Wellcome Sanger Institute, this collection of 40+ papers marks significant progress in our understanding of the human body.    Congratulations to everyone involved in this global collaboration 👏   Head over to Nature to find out more ⬇️ https://lnkd.in/eCNeb7-Y

We're #hiring a new Advanced Research Assistant | CellOps | 12-months fixed-term in Hinxton, England. Apply today or share this post with your network.

It’s day two of #GlobalEntrepreneurshipWeek and we’re kicking off Startup School today, our entrepreneurial programme tailored to #genomics and #biodata scientists. This year’s cohort of 29 participants, from both the Sanger Institute and the European Bioinformatics Institute | EMBL-EBI will go through: - Six months of entrepreneurial training, where they'll hear from eminent entrepreneurs, discuss intellectual property, learn how to find funding, to approach challenges in an innovative way, customer interviews, business models, and more! - Tailored mentoring and access to a wider pool of mentors specialising in the translation of genomics within industry and academia - Networking and external opportunity events to meet other scientists, founders and investors within our field Our new cohort are at the start of their entrepreneurial journey, with thirteen ideas stemming from our #genomics and #biodata science on campus. Want to learn more about Startup School? Our fourth cohort finished earlier in the year and we compiled their experiences in this blog ➡ https://lnkd.in/etPJE35w

🎓 Churchill Scholar Arnav Lal recently completed an MPhil in Biological Science at Churchill College, where he researched antimicrobial resistance at the Wellcome Sanger Institute. Arnav is featured in the Sanger's latest 'Meet the Scientist' blog which explores his passion for merging clinical practice with infectious disease research, his experiences at Cambridge and his next step – starting his studies at Harvard Medical School! 👉https://ow.ly/RQw550U3faf Image credit: Jake Bonham / Jet Photographic #ChurchillCollege #CambridgeUniversity #InfectiousDisease #HarvardMed #postgraduate The Winston Churchill Foundation of the United States

We're #hiring a new Scientific Manager | 12 month fixed-term in Hinxton, England. Apply today or share this post with your network.

For #GlobalEntrepreneurshipWeek we want to highlight our #entrepreneurs and #innovators at the Sanger Institute. Entrepreneurial thinking allows our scientists to innovate in the work they do and to think about how their research can have an impact, to take an idea stemming from our labs to a product or service that will impact human or planetary health. Entrepreneurs and innovators such as... Valentina Migliori, who is working to make the science we do in our labs more clinically relevant ➡ https://lnkd.in/eM9_W-2a Jyoti Nangalia, who is combining her clinical, academic and genomic expertise to advance our understanding of blood cancers, from diagnosis to predicting patient outcomes and improving clinical management. ➡ https://lnkd.in/eezj-XV9 Our current Sanger Director, Matthew Hurles, who co-founded Sanger spin out Congenica, which is now the exclusive Clinical Decision Support Partner for the National Health Service (NHS) Genomic Medicine Service. ➡ https://lnkd.in/eyWUj83s Qianxin Wu, who has a love for problem solving. She developed INSIGHT, a technology for the detection of viral pathogens, and is now working on a personalised CRISPR library, which she hopes will be a significant step towards refining drug discovery in a personalised way. ➡ https://lnkd.in/e3rHxvAC Inigo Martincorena, who is the academic co-founder of Quotient Therapeutics, the world’s first Somatic Genomics platform which hopes to enable a new generation of drug discovery and medicines. ➡ https://lnkd.in/eetZ88xg Physilia C., who has now left the Sanger Institute, but who worked to adapt three existing high-throughput DNA sequencing protocols to an ONT (Oxford Nanopore Technology) platform. A small, portable and affordable sequencing machine which could open the door to sequencing anything, anytime, anywhere. ➡ https://lnkd.in/e3W5-TmG

We're #hiring a new Senior Staff Scientist | 12 month fixed-term in Hinxton, England. Apply today or share this post with your network.