SSPC, Research Ireland Centre for Pharmaceuticals

"The aim, ultimately, is not to cause further damage to the skin," said Dr. Robert Elmes, Associate Professor in the Department of Chemistry at Maynooth University and an Investigator at SSPC, the Science Foundation Ireland Research Center for Pharmaceuticals. "We use supramolecular chemistry as the basis for research, studying how molecules interact with each other and how we can predict how they will separate from each other as they cool. "This is an excellent example of a fundamental area of chemical science having a potentially life-changing impact on the everyday lives of people with EB." https://lnkd.in/ezTXehs8

Irish research into new bandaging aims to ease the agony experienced by those living with genetic skin condition Epidermolysis Bullosa (EB),  co-funded by Debra, the national charity supporting those living with EB. Scientists at Maynooth University, are leading research into whether ‘spray on, wash off’ bandages will be a viable alternative to those currently used, which can cause severe pain when applied and removed. Associate Professor Rob Elmes, Research Project Supervisor and SSPC investigator said: “We use supramolecular chemistry as the basis to the research, studying how molecules interact with each other and how we can predict how they will separate from each other as they cool. This is an excellent example of a fundamental area of chemical science having a potentially life-changing impact on the everyday lives of people with EB. Pricing for the bandages is not expected to be out of reach of those living with EB as the materials used are widely available and completely harmless to the skin. ▶https://lnkd.in/e62FdrxX Hilal KIRPIK #Recessive #Dystrophic #proteins #bandages #SSPCExpertise #health

Making medicine, using your body to generate electricity and time travel - all in a days work at University of Limerick for Science Week This morning Martin McHugh, from SSPC, Research Ireland Centre for Pharmaceuticals gave local students an insight into making medicine at a Medicine Maker Workshop. Elsewhere Associate Professor Sarah Guerin and her team put students through their paces to measure the amount of piezoelectricity they could generate using tiles that generate a pulse of electricity every time someone steps on them. Our alumnus Barry W. Fitzgerald was also with us today to discuss all things time travel and look at 4 different ways we could possibly travel into the future using advanced technologies! Thanks to everyone who helped to put these events together! #Scienceweek Research Ireland

📌Meet the SSPC experts in the Hybrid Molecules & Bioconjugation space, part two... Bioconjugation and molecular hybrids are at the forefront of pharmaceutical innovation, offering transformative solutions for targeted drug delivery and enhanced therapeutic efficacy. SSPC's expertise provides bespoke solutions that address complex industry challenges, driving innovation in drug substance research and manufacturing processes for the pharmaceutical and biopharmaceutical sectors. ▶https://lnkd.in/ekwzCyPp Research Ireland #pharma #thioquinolines #peptides #green #Naphthalimide  #crystalengineering #lipids #biomoecule #delivery #gene #therapy

Excited to share our recent work on “Evaluation of aspartame as a co-former in the preparation of co-amorphous formulations of dipyridamole using spray drying”. In this study, we explored the use of spray drying technology to prepare dipeptide-based co-amorphous systems, comparing them with formulations using individual amino acids and amino acids mixtures. By employing Hirshfeld Surface analysis and spectroscopic, we identified key molecular interactions that enhance the properties of the dipeptide-based co-amorphous formulation. Additionally, we applied the Arrhenius Equation to develop a predictive model for crystallization behavior under accelerated conditions, using non-ambient X-ray diffraction technology. A big thank to SSPC, Research Ireland Centre for Pharmaceuticals for funding this project and to the co-authors and supervisors Niall O'Reilly, Peter McLoughlin and Helen Cathcart for their incredible support and contribution. Special thanks to PMBRC of South East Technological University for providing the wonderful research facilities. We welcome your thoughts on our work and any suggestions you may have. Happy reading 😊 #coamorphous #spraydrying #acceleratedstability #Arrheniusequation #xray #diffraction #HirshfeldSurface

Bioconjugation and molecular hybrids are at the forefront of pharmaceutical innovation, offering transformative solutions for targeted drug delivery and enhanced therapeutic efficacy. These technologies enable the precise attachment of drugs to biological molecules and other molecular cargo, improving stability, solubility, and specificity. SSPC has a critical mass of renowned researchers in this area and the Centre plays a pivotal role in this field, leveraging its advanced research capabilities and talented researcher pool to develop cutting-edge advancements. SSPC's expertise provides bespoke solutions that address complex industry challenges, driving innovation in drug substance research and manufacturing processes for the pharmaceutical and biopharmaceutical sectors. 📌At a glance, read part 1 of SSPC's Hybrid Molecules & Bioconjugation spotlight: ▶https://lnkd.in/eburAx4k Research Ireland #bioimaging #flow #bioconjugatiuons #theranostic #ligands #protein #therapeutics #antimicrobial #MOFs #pharmaceuticals #SSPCExpertise

I had the unique opportunity to present my PhD research on Automated 3D Printed Experimental and Manufacturing Platforms at the Continuous Process: Next Generation Advancements session at the Annual AIChE - American Institute of Chemical Engineers Conference in San Diego. This session, part of the Pharmaceutical Discovery, Development, and Manufacturing Forum, highlighted cutting-edge advancements in continuous processing for active pharmaceutical ingredient (API) development and manufacturing. With continuous processing offering major advantages over traditional methods, industry and academic researchers are pushing boundaries in this field. Automation and high-throughput experimentation (HTE) coupled with Machine Learning can reduce experimental burden, enhance sustainability, and improve control. A deep appreciation to everyone who attended and contributed to the discussion, to SSPC, Research Ireland Centre for Pharmaceuticals, for their support, and to my mentors, Steven Ferguson and Ioscani Jiménez del Val for their invaluable guidance throughout this project.

Check out a recent publication in Organic Process Research & Development. 📌An amazing output showcasing SSPC expertise, industry collaboration with Eli Lilly and Company, featuring SSPC #talent. Lead author and SSPC alumnus Michael Carroll, Eli Lilly and Company, Aobha Hickey, Ava Rogers, a University of Limerick Bachelor of Science in Pharmaceutical and Industrial Chemistry placement student at Lilly, Cáoimhe Niland and Rachel O Sullivan, SSPC industry placement PhD students at the time, Muniraj Nachimuthu, Kevin O’Sullivan, Pat Guiry, University College Dublin, Michael Murray Improved reaction conditions have been developed for a telescoped Miyaura borylation/Suzuki coupling process, which is utilized in the synthesis of an abemaciclib intermediate. Key improvements include the in situ generation of a lipophilic base and tailored ligand selection for each palladium-catalyzed step. Optimizing ligand choice significantly reduced aryl scrambling, a major source of impurities in the borylation step. Additionally, the process improvements led to shortened reaction times and lower palladium loadings, resulting in a more efficient, higher-yielding process. https://lnkd.in/gQmXjpeM Research Ireland #Borylation #Inorganic #carbon #compounds #Ligands #Organic #compounds #Potassium

Wise words from Michael Lohan on the importance of partnership for success - industry, government, agencies, universities - at today’s opening at J&J Innovative Medicine. SSPC, Research Ireland Centre for Pharmaceuticals IDA Ireland

#Postdoc Research Fellow position available 📌Level 1 or 2, University College Dublin Chemistry Application Deadline: 19 Nov 2024 - 03:17 (UTC) The Project is part of a European Consortium that seeks to prospect natural lignin biodiversity towards unlocking value-added bioactive motives and molecules (EU acronym: PROSPLIGN). Prior to application, further information (including the application procedure) should be obtained from the Work at UCD website: https://lnkd.in/d5S9Sxm #chemistry #inorganic #chemistry #euproject Research Ireland