BRIC-National Institute of Immunology’s Post

These are 6-day-old neurons derived from an 8p hero stem cells, or iPSCs at the UConn Health Pinter Lab. In green, you can see the CRISPRai construct. In magenta, you can see the reporter for the RHOBTB2 guide, an interesting gene that is duplicated in many heroes. Join our next monthly Roundtable to learn more. #8pheroes #chromosome8p #rarediseases #TogetherTowardsTreatment

🥇 A world 1st! For the first time, our newly expanded opti-ox powered CRISPR-Ready ioCells toolkit gives you off-the-shelf access to functional human iPSC-derived microglia and glutamatergic neurons, built for the easy and routine generation of gene knockouts and CRISPR screens. Even if this is your first time using CRISPR or iPSC-derived cells, you can use CRISPR-Ready ioCells with our optimised protocols to start obtaining readouts in a matter of days. Everything is optimised for you. Discover the cells: https://lnkd.in/erSR6BTn #research #DrugDiscovery #CRISPR #CRISPRscreens #TargetID #ioCells #optiox

🥇 A world 1st! For the first time, our newly expanded opti-ox powered CRISPR-Ready ioCells toolkit gives you off-the-shelf access to functional human iPSC-derived microglia and glutamatergic neurons, built for the easy and routine generation of gene knockouts and CRISPR screens. Even if this is your first time using CRISPR or iPSC-derived cells, you can use CRISPR-Ready ioCells with our optimised protocols to start obtaining readouts in a matter of days. Everything is optimised for you. Discover the cells: https://hubs.ly/Q02M3pPw0 #research #DrugDiscovery #CRISPR #CRISPRscreens #TargetID #ioCells #optiox

💫 BMKMANU S1000 Spatial Transcriptomics Project Experience - Olfactory Bulb in 🐭Mouse Brain Using single-cell level spatial transcriptome technology, BMKMANU S1000, the olfactory bulb sample in the mouse brain was detected, obtaining a total of transcripts and spatial positional information of 17,564 cells. With the help of BMKMANU cell segmentation technology, the cell types of the olfactory bulb sample were accurately identified, and the spatial distribution of the main olfactory bulb nerve layer, glomerular layer, external plexiform layer, internal plexiform layer, mitral valve layer, granule layer, and subependymal zone was reconstructed. Number of segmented cells: 17,564  Median gene count at single-cell resolution: 1142 Contact us now to talk about your project requirements: https://lnkd.in/dEwG33Jd #SpatialTranscriptomics #BMKGENE #BMKMANUS1000 #singlecell

Exciting new research, utilizing the Target ALS Human Postmortem Tissue Core, has revealed that prion-like SOD1 protein aggregates are present in ALS patients without a SOD1 gene mutation. This breakthrough, led by Dr. Moses Leavens from the McLaughlin Research Institute for Biomedical Sciences, suggests that diagnostic biomarkers for familial ALS may also benefit sporadic ALS cases, which account for 90% of ALS diagnoses. With support from Target ALS, ongoing studies aim to validate these findings and advance diagnostic tools. Read the full blog and published work here: https://bit.ly/4dv9a02 Learn more about how our resources are accelerating ALS research at low to no cost to scientists worldwide: https://bit.ly/4dvk1HB #EveryoneLives #ALS #ALSResearch

BMKMANU S1000 Spatial Transcriptomics Project Experience - Olfactory Bulb in Mouse Brain Using single-cell level spatial transcriptome technology, BMKMANU S1000, the olfactory bulb sample in the mouse brain was detected, obtaining a total of transcripts and spatial positional information of 17,564 cells. With the help of BMKMANU cell segmentation technology, the cell types of the olfactory bulb sample were accurately identified, and the spatial distribution of the main olfactory bulb nerve layer, glomerular layer, external plexiform layer, internal plexiform layer, mitral valve layer, granule layer, and subependymal zone was reconstructed. Number of segmented cells: 17,564  Median gene count at single-cell resolution: 1142 Contact us now to talk about your project requirements: https://lnkd.in/dEwG33Jd #Spatial Transcriptomics #BMKGENE #BMKMANU S1000 #single cell level

Fanzor2, a eukaryotic CRISPR-Cas homolog, characterized using advanced cryo-electron microscopy. This breakthrough, led by Elizabeth Kellogg and team at St. Jude Children's Research Hospital, could revolutionize gene editing by providing new insights into the mechanisms of CRISPR systems in eukaryotes. Really excited about this as it will be adding to the toolbox we may use for therapeutic applications. #CRISPRCas9 #GeneEditing #structuralbiology

Yes, you always wanted to see it it ACTION.....🔥🔥🔥 . . . Dear CLD in Bioprocessing Community members, Emma Morris and I are very excited to announce that on Thursday May 30th we will be delivering a unique virtual demo of Cell Metric X HT Clone Imager! 🤩 Here is the plan: ✅ We will walk you through step by step on how to use it (it's so easy you will see!💛) including the CMX ability to capture evidence of clonality, automate clonal outgrowth analysis, and track colony growth rates using Artificial Intelligence (AI) and all that good stuff 😉 ... ✅ We will show you how our InstiGRO and InstiSHAKE supplements boost the expansion of HEK293 cells, paving the way for scalable gene therapies. 🌟 Don't miss out on mastering these technologies to propel your gene therapy projects to the next level. Emma and I will be there to answer all your questions. 📅 Save the date and register now to revolutionize your approach to novel gene therapies! Link to register 👉🏻click on the post below #GeneTherapy #CellLineDevelopment #Biotechnology #Innovation

📝 Our Blog：The Germline's Role in Mitokine Signaling: Unraveling Inter-tissue Communication。This study explores how germline mitochondria influence the signaling between neurons and peripheral tissues like the intestine, providing new insights into mitochondrial health and organismal longevity.   💡 Contribution of SunyBiotech: SunyBiotech played a critical role in supporting this research by creating specific C. elegans strains that were essential for exploring the function of the ucr-2 gene family in mitokine signaling: Click to read more :https://lnkd.in/gY2SEpAb

Role of silent potassium channel in amyotrophic lateral sclerosis (ALS) The potassium cahnnel Kv8.1, encoded by the KCNV1 gene, is a ‘silent’ ion channel subunit whose biological role is complex since Kv8.1 subunits do not form functional homotetramers but assemble with Kv2 to modify its ion channel properties. Through RNA sequencing & ion channel profiling, the researchers discovered that in ALS patient derived motor neurons, reduced Kv8.1 expression levels and increased cell death susceptibility without altering neuronal excitability. The studies also revealed dysregulated metabolism and lipid/protein transport pathways in KCNV1/Kv8.1-deficient motor neurons.  #sciencenewshighlights #ScienceMission https://lnkd.in/gyFp8svH https://lnkd.in/g8rcz7S6