Promega UK

An endogenously tagged HiBiT neosubstrate panel, made up of six targets for iMiD molecular glues (IKZF1 and IKZF2 (Jurkat), IKZF3 (MM.1S), SALL 4 (SK-N-DZ), CK1α and GSPT1 (HEK293)), is available for screening for molecular glue library degradation selectivity and off-target effects with CRBN-recruiting PROTACs. Select these cell lines on this Ordering Options form or contact your account manager to receive an end-of-year discounted bundle price, until 6 December 2024! #molecularglues #TPD #proteintagging #CRISPR #hibit

Welcome to the November issue of our Newsletter, to enjoy ideally with a hot drink on a snowy day! This month, for our UK and Irish customers, we are starting with festive news - how to stock up with chocolate as well as providing a little pre-festive fun, with an invitation to design your own festive lab coat (you only have until 3.00 pm on Friday 22 November 2024 to request your design studio and then submit before Monday 25 November, when voting starts!) Also, in this edition, we have information about the new Arg-C Ultra, the latest addition to your mass spectrometry toolkit, as well as information about Lumit® Complete Assays, for fast, no-wash quantification of phosphorylated and total cell signalling proteins. #MassSpec #assays #ScienceFun

It's nearly here, the GloMax® Galaxy Bioluminescence Imager, designed to elevate your research with real-time imaging of NanoLuc® technologies. This instrument offers the clarity and sensitivity you need to observe cellular processes as they unfold, from protein interactions to target engagement. Discover how the GloMax® Galaxy can enrich your research and provide new insights. Learn more: https://bit.ly/490awPP #LabInstruments #CellularImaging #bioluminescence

Make a difference this festive season! Swap your hamper for a donation to Macmillan Cancer Support - We will donate £100 for £1500 (€1800)+ orders, £250 for £5000 (€6000)+ (UK and Ireland only. Terms and Conditions apply, see our website for more information) #PromegaChristmas

Profile Compound Selectivity Against 192 Kinases in Live Cells. The NanoBRET™ Target Engagement (TE) K192 Kinase Selectivity System can quantitatively measure intracellular compound occupancy against a panel of 192 kinases in a single experiment. The system relies on the NanoBRET™ TE technology, a bioluminescence resonance energy transfer (BRET) method that uses the small, extremely bright NanoLuc® luciferase as the energy donor and a cell-permeable NanoBRET™ TE Tracer as the energy acceptor. The K192 Kinase Selectivity System is a live-cell method using an addition-only, multiwell plate format with a single NanoBRET™ TE Kinase Assay. The NanoBRET™ TE K192 Kinase Selectivity System is optimised for each kinase to provide quantitative occupancy data, enabling cellular profiling of compound-kinase interactions. More at: https://bit.ly/3CNLcAs #kinase #nanobret #cellhealth

Promega UK’s Christmas Hamper promo is now live! 🎁 Spend £1500 (€1800)+ for a ‘Chilworth’ hamper of luxury chocs, or £5000 (€6000)+ for the ‘Winchester’ hamper (pictured). Claim at - https://bit.ly/40SnLjw (T&Cs apply, UK and Ireland only, ends 13 Dec 2024) Alternatively, skip the chocolate and turn your hamper into a donation from Promega UK to this year's Christmas charity Macmillan Cancer Support. Promega UK will donate £100/€120 donation available on orders over £1500/€1800 or £250/€300 donation on orders over £5000/€6000. #PromegaChristmas #LabLife #PromegaHamper

Don't forget to join us tomorrow, Wednesday 20 November 2024 at 3.00pm (GMT) for our free webinar - Always Look on the Bright Side of (Cell) Death: Cytotoxicity Assays for Antibody Drug Conjugate Development. In this webinar you will learn: • The benefits of drug screening in 3D cell cultures and how using optimised 3D cell-based assays address the challenges of measuring cell health in 3D cultures, leading to more effective assessment of key outcomes, such as viability and apoptosis. • The role of bioassays in ADC developability and lead selection • How complex co-culture and 3D in vitro models enable researchers to select the best candidate to take forward for clinical development Your presenters will be: o Darren Heywood, Product Manager, Cell Health, Promega UK o Grant Harradence, Manager, Abzena o Robert Francis, PhD, Manager & Microscopy Lead, Abzena Abzena is a leading biopharmaceutical CDMO and CRO offering fully integrated, customised drug development and manufacturing services from early discovery to clinical trials. In this webinar, Darren Heywood from Promega will introduce plate-based cell health assays for drug development and screening in 3D cell cultures. Register at https://bit.ly/4hRF7mP #HTS #3DCellCulture #CellHealth

🎉 We’re proud to announce that Promega UK has passed our ISO 14001 surveillance audit with flying colours! 🌍 No issues were found during the audit, which highlights our continuous commitment to sustainability and responsible practices across all our operations. A big thank you to our team for their efforts in making this possible! 👏 #Sustainability #ISO14001 #LifeAtPromega

We asked Joanne Kelsall, Lead Commercial Scientist at ImmuONE, why she preferred Lumit to ELISAs: “Lumit is much quicker, more straight forward and time efficient, I was done by lunchtime” Discover more about Lumit for yourself at https://bit.ly/48W8Nev #ELISA #HTS

🎄 Will you be joining in on our special Christmas game – Design a Lab Coat? 🧪✨ Take a look at some of the creative early entries we’ve received to get inspired! If you’re looking for ideas on how a completed entry might look, these designs are a great start. 🎨 We can’t wait to see your festive take on the lab coat! 🎅🔬 You have until Friday, 22 November 2024 (inclusive) to submit your design requests at https://bit.ly/3Z6LfQC For every design submitted we’ll donate £1 to Macmillan Cancer Support (up to £5,000/€6000). All designs submitted in time will be featured on our Promega website, where people will be invited to vote for their favourites, so we can select a final winner (every voter will be entered into a prize draw to win a Promega Lego Lab so there is something for everyone joining in the fun!) #PromegaChristmas #ScienceFun #ChristmasLabCoat