ARTIKEL - Januari 2014, Vol.10, No.03
Keefektifan ekstra putih telur terhadap peningkatan albumin dan penurunan IL-ß pada pasien tuberkulosis dengan hipoalbuminemia
Agus Prastowo1, Wiryatun Lestariana2, Siti Nurdjanah3, Retno Sutomo4
Background : Tuberculosis (TB) is world health problem which still needs attention. Recently, Indonesia ranks the third in TB prevalence after India and China. Research revealed that albumin decrease signifi cantly in TB patients, due to lack of nutritions intake such as low calorie intake, anorexia, increased catabolism, enteropathy and acute protein reaction. Low albumin were associated with increased IL-ß and cytokines infl ammation in TB patient. Albumin had a very important role in the body and white egg known as a good quality source of protein.
Objective : To assess the effect of white egg supplemention in TB patient towards the level of albumin and the level of IL-ß.
Method : A single blind randomized controlled trial was conducted with 75 patient selected for the study and divided to 37 patient as study group and 38 as control group. Both groups received high energy high protein diet, while the study group received, additionally, an oral egg white-based on formula calculation Baxter for 14 days. Control group received, additionally, an extra soybean curd and mungbean powder. Albumin and IL-ß was checked before and after the intervention. Data is analyzed by using Mann-Whitney.
Result : Research results show that average albumin pre-intervention in the study group was 2.82 g/dL and control group was 2.85 g/dL. Average albumin difference in study group was 3.47 g/dL and control group was 2.81 g/dL. Bivariate analysis results show signifi cant of increasing albumin between study group and control group (p<0.05). Research results show average IL-ß pre-intervention difference in study group (0.9 pg/mL) and control group (0.67 pg/mL). Average IL-ß difference in study group was -0.39 pg/mL and control group was 0.76 pg/mL. Bivariate analysis results show signifi cant difference of IL-ß depletion between study group and control group (p<0.05).
Conclusion : Egg white increase albumin level and IL-ß depletion in tuberculosis patients effectively.
Key words : egg white, albumin, IL-ß, tuberculosis patients
1 Korespondensi : Program Magister Fakultas Kesehatan Masyarakat Universitas Airlangga Surabaya, Kampus C Mulyorejo 60115, e-mail: pudjiastutik51@ yahoo.com
2 Bagian Biokimia, Fakultas Kedokteran Universitas Gadjah Mada, Jl. Farmako, Sekip Utara, Yogyakarta 55281
3 Bagian Penyakit Dalam, Fakultas Kedokteran Universitas Gadjah Mada, Jl. Farmako, Sekip Utara, Yogyakarta 55281
4 Bagian Anak, Fakultas Kedokteran Universitas Gadjah Mada, Jl. Farmako, Sekip Utara, Yogyakarta 55281
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Efek hipoglikemik tepung komposit (ubi jalar ungu, jagung kuning, dan kacang tunggak) pada tikus diabetes induksi streptozotocin
Carolina Sisca Djunaidi1, Dian Rachmawanti Affandi1, Danar Praseptiangga1
Background : The composite fl our (50% sweet potato, 30% corn, and 20% cowpea) had proven that it could substitute 100% wheat fl our for biscuit making. Intake of antioxidants, dietary fi ber, and protein, had been known to reduce plasma glucose level.
Objective : To evaluate the effect of composite fl our diet on plasma glucose levels, body weight and food consumption of streptozotocin (STZ)- diabetic rats.
Method : Thirty male Sprague-Dawley rats aged + 2 months (+ 200 grams), were divided into three groups of ten rats. They were (1) non-diabetic standard diet (ND-STD), (2) diabetic (65 mg/kg of body weight by STZ induction) standard diet (D-STD), and (3) diabetic composite fl our diet (1,5 g/100 g of body weight/day) (D-CFD), for 4 weeks, 3 days after STZ induction. The plasma glucose obtained from GOD-PAP method were determined before induction, after induction and every week during diet intervention.
Result : Plasma glucose levels was signifi cantly lower in D-CFD when compared with D-STD (p<0,05). The weight of D-STD was found to be signifi cantly decreased as compared to ND-STD (p<0,05). There were no changes in food consumption of ND-STD, D-STD and D-CFD (p<0,05).
Conclusion : The composite fl our could reduce plasma glucose level on diabetic rats and did not give negative effects on body weight and food consumption.
Key words : diabetic, streptozotocin-induced, composite fl our, hypoglycemic effect
1 Korespondensi : Program Studi Ilmu dan Teknologi Pangan, Universitas Sebelas Maret Surakarta (UNS), Jl. Ir. Sutami 36A, Kentingan, Surakarta 57126; e-mail:
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Asupan zink dan magnesium makanan dengan disfungsi ereksi pada penderita sindrom metabolik
Saraheni1, I Dewa Putu Pramantara2, Herni Astuti3
Background : Metabolic syndrome (MetS) is a disease of disorder of lipid and non lipid metabolism. The West of Scotland Coronary Prevention Study found that men with MetS had probability 3.7 dysfunction of erection (ED) by using International Index of Erectile Function (IIEF). Patient with heart disease had risk 2 times to get ED, hypertension was 1.5-2 times, DM was 3-4 times, depression was 2-3.5 times, testosterone defi ciency syndrome (TDS) was 1.5-2 times, and high cholesterol was 4 times. The nutrient defi ciency of zinc (Zn) and magnesium (Mg) was suspected being the main component which had role in resisting a sexuality growth and maturation process.
Objective : Knowing the correlation of Zn and Mg feeding with erection dysfunction in MetS person.
Method : This study was observational analytic study, with case control design in patient aged 30-60 years old. The respondent in this study was people with MetS according to WHO criterion. There was 82 patient devided in to two groups, consist of 41 cases with MetS and ED, 41 cases with normal patient. The data collected by interview, laboratory assessment and antropometric measurement. The data analysis using univariate, bivariate and multivariate analysis using multiple logistic regression.
Result : There was signifi cant correlation between Zn feeding and ED (OR=7.15; 95% Cl=1.47-34.71; p=0.007) and there was signifi cant correlation between Mg feeding with ED (OR=3.34; 95% Cl=1.07-10.4; p=0.033). The end result of multivariate analysis showed the risk variable to the ED event, that were Zn feeding with OR=15.41. If the intake of Zn accompanied with risk factors associated as a cause of ED, multivariate analysis showed HbA1c’s degree with OR=12.57; triglyceride (OR=10.47); blood pressure (OR=5.82); and abdominal obesity (OR=6.94). Result shows that these risk factors can aggravate or anticipate the onset of disfunction erection beside low Zn intake.
Conclusion : There were statistically signifi cant correlation between Zn and Mg feeding with erection dysfunction in MetS patient.
Key words : metabolic syndrome, erection dysfunction, zinc and magnesium
1 Korespondensi : Instalasi Gizi Rumah Sakit Umum Daerah (RSUD) Abdul Wahab Syahranie Samarinda, Jl. Palang Merah Indonesia, Samarinda, Kalimantan Timur, e-mail:
2 Bagian Penyakit Dalam Rumah Sakit Umum Pusat (RSUP) Dr. Sardjito, Jl. Kesehatan No. 1, Sekip, Yogyakarta 55284
3 Instalasi Gizi Rumah Sakit Umum Pusat (RSUP) Dr. Sardjito, Jl. Kesehatan No. 1, Sekip, Yogyakarta 55284
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Faktor risiko sarapan pagi dan makanan selingan terhadap kejadian overweight pada remaja sekolah menengah atas
Shelly Festilia Agusanty1, Istiti Kandarina2, I Made Alit Gunawan3
Background : Overweight or obesity during childhood and adolescence are important risk factors for the presence of adult overweight or obesity. Eating habits in childhood and adolescence infl uence their healthy condition. Prospective studies of breakfast habits and nutritional status suggest an inverse (protective) association between the frequency of eating breakfast and the risk for overweight and obesity and relationships between no breakfast and increasing body weight.
Objective : To examine risk factor of breakfast and snacking related to overweight status in adolescents.
Method : This was observational study with case control design. First step of study was screening to have prevalence of overweight in adolescents. The second step was case control study participated by 100 overweight adolescents and 100 normal weight adolescents in senior high school matched in sex, age and school. Data collected were weight and height measurements for nutritional status, respondent identity and characteristic, breakfast dan snacking habits and physical activity. Statistical analysis used Chi-Square statistics and multivariable logistic regression analysis.
Result : Prevalence of overweight in adolescents were 16,8%. There were signifi cant association between breakfast with overweight (p<0,05; OR=3.1; 95% CI=1.4-7.47). There was no association between snacking and overweight, but there were signifi cant association between frequency of snacking (OR=1.9; 95% CI=1.05-3.50), energy of snacking (OR=2.1; 95% CI=1.13-4.02), and carbohydrate of snacking (OR=4.5; 95% CI=1.94-11.50) with overweight. In multivariate model, breakfast habits, carbohydrate of snacking and physical activity had signifi cant association with overweight.
Conclusion : Skipping breakfast was a risk factor for overweight in adolescence. Adolescents who had snacking more than twice a day were having greater risk factor for overweight.
Key words : breakfast, snacking, overweight
1 Korespondensi : Jurusan Gizi, Politeknik Kesehatan Kementerian Kesehatan Pontianak, Jl. 28 Oktober Siantan Hulu Pontianak, Kalimantan Barat, e-mail:
3 Jurusan Gizi, Politeknik Kesehatan Kementerian Kesehatan Yogyakarta, Jl. Tata Bumi No. 3 Banyuraden Gamping, Sleman, Yogyakarta
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Konflik peran kerja-keluarga pada ibu bekerja terhadap perilaku obesogenis anak sekolah dasar
Almira Sitasari1, Madarina Julia2, Toto Sudargo3
Background : Childbearing pattern of parents greatly affects healthy lifestyle of children including behaviors preventing children from obesity. Working mothers with dual role at work and the family face challenges in doing so.
Objective : To identify effect of work-family confl ict in working mothers to obesogenic behaviors of elementary school children at Yogyakarta Municipality.
Method : This was a quantitative study with cross sectional design. Obesogenic behaviors was assessed using questionnaire of Family Health Behavior Scale. Role confl ict was assessed using questionnaire of Work-Family Confl ict fi lled by working mothers. Nutrition status of children was assessed using parameter of body mass index by age with standard of WHO 2007.
Result : The result of the study showed 47.73% of working mothers had high role confl ict and 45.26% of children had high obesogenic behaviors. There was no effect of work-family confl ict in working mothers to obesogenic behaviors of elementary school children at Yogyakarta. The infl uencing factors were family income (p<0.001); position/job type (p<0.001); gender (p<0.05); and nutrition status (p<0.05).
Conclusion : Work-family confl ict in working mothers had no effect to obesogenic behaviors of elementary school children at Yogyakarta Municipality.
Key words : role conflict, working mothers, obesogenic behaviors, school children
1 Korespondensi : Jurusan Gizi, Politeknik Kesehatan Kementerian Kesehatan Yogyakarta, Jl. Tata Bumi No. 3 Banyuraden Gamping, Sleman, Yogyakarta, e-mail:
3 Program Studi Gizi Kesehatan, Fakultas Kedokteran Universitas Gadjah Mada, Jl. Farmako, Sekip Utara, Yogyakarta 55281, e-mail: toto_sudargo@yahoo. co.id
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Sanitasi, infeksi, dan status gizi anak balita di Kecamatan Tenggarong Kabupaten Kutai Kartanegara
Andi Tenri Abeng1, Djauhar Ismail2, Emy Huriyati3
Background : Malnutrition is a public health problem commonly encountered in developing countries. Almost 50% of 10-11 millions of mortality among children under-fi ves caused by malnutrition that are preventable. District of Kutai Kartanegara is known as the most wealth of district in Indonesia, yet the wealth cannot automatically solve the problem of its people. Numerous efforts have been made to solve malnutrition problem yet the morbidity rate is still relatively high.
Objective : The study aimed to identify association between sanitation with infection and nutritional status of underfi ves at Subdistrict of Tenggarong, District of Kutai Kartanegara.
Method : The study was observational with cross sectional design. Samples consisted of 187 underfi ves of 7-60 months taken using proportional random sampling technique. Variable of sanitation was obtained from interview with subjects using questionnaire and direct observation. Variable of infection was obtained from interview with subjects and cross check at health centers. The dependent variable of nutritional status was based on anthropometric assessment using weight/height index. Bivariate analysis used Chi-Square and multivariate analysis used logistic regression.
Result : The result of statistical test showed there was signifi cant association between sanitation and infection (acute respiratory tract infection/ARI, diarrhea) of underfi ves (p<0.05). There was association between ARI and diarrhea with wasted children (p<0.05).
Conclusion : There was signifi cant association between sanitation, infection and nutritional status of underfi ves at Subdistrict of Tenggarong District of Kutai Kartanegara.
Key words : environmental sanitation, infection disease, nutrition status, underfives
1 Korespondensi : Dinas Kesehatan Kabupaten Maros, Jl. Bougenvile Kompleks Kantor Bupati Maros, e-mail:
2 Bagian Ilmu Kesehatan Anak, Rumah Sakit Umum Pusat (RSUP) Dr. Sardjito, Jl. Kesehatan No. 1, Sekip, Yogyakarta 55284
3 Program Studi Gizi Kesehatan, Fakultas Kedokteran Universitas Gadjah Mada, Jl. Farmako, Sekip Utara, Yogyakarta 55281, e-mail: emy_huriyati@yahoo. com
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