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Jurnal Vol.9 No.4

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ARTIKEL - April 2013, Vol.9, No.4

Intervensi biskuit tempe kurma bagi peningkatan status gizi balita penderita tuberkulosis

Fatmah1

ABSTRACT

Background
: Weight gain as an indicator of nutritional status during tuberculosis drugs management has a signifi cant relationship with the rapid conversion of sputum smear, low incidence of relapse and duration of anti tuberculosis drugs in patients with tuberculosis. Low intake of food in patient suffering from an infectious disease is caused by the emergence of anorexia, nausea, vomiting, and increased body temperature. Inadequate nutrient intake affect the immune system, lower resistance to infection and slow healing resulting progessive tuberculosis (TB).
Objective : To assess the effect of tempeh dates biscuit consumption on the change of nutritional status of tuberculosis preschoolers patients.
Method : A quasi experimental design towards 52 underfi ve children with TB status and who were underweight was done in all sub districts at Depok City. There were three groups participated in the study i.e tempeh dates biscuits as intervention group, and two groups of control (tempeh and placebo biscuits). The nutritional status of subjects was assessed each biweekly by giving daily 50 grams of biscuits within four weeks. Data analysis was using paired t-test and Anova.
Result : There were greatest weight gain in subject who received tempeh dates biscuit by 0.5 kg and largest height improvement in the tempeh biscuits group by 1.8 cm. Weight, height, and z-score weight/age had signifi cant differences in the three groups at the end of the study. There were signifi cant differences on carbohydrate intake in the intervention group at pre and postintervention. Tempeh biscuits group had different levels of mothers’ knowledge on nutrition and TB at the end of the study.
Conclusion : Tempeh dates biscuit can be recommended as an alternative supplementation feeding program for TB and non TB underfi ve children with underweight status.

Key words : tempeh dates biscuit, underfi ve tuberculosis children, underweight

1 Departemen Gizi Kesehatan Masyarakat, Fakultas Kesehatan Masyarakat Universitas Indonesia, Gedung F Lt. 2 Ruang F202 Kampus UI Depok 16424, Telp. (021) 7863501, Fax. (021) 7863501, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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Status pemberian ASI terhadap status gizi bayi usia 6-12 bulan

Normayanti1, Nila Susanti2

ABSTRACT

Background
: Coverage of exclusive breastfeeding in Indonesia fl uctuate and showed a declining trend over the last three years. Coverage of exclusive breastfeeding of Palangka Raya city is still very low at around 23.30%. There are several variables suspected as the cause of the malnutrition problem, the variables are status of breastfeeding, mother's education level, mother's employment, mother’s knowledge of nutrition and counseling status of breastfeeding.
Objective : This study aimed to determine the effect of breastfeeding status on the nutritional status of infants aged 6-12 months in the working area of UPTD Puskesmas Kalampangan Palangka Raya city.
Method : The study design used was a case-control with 1:2 ratio, the case are infants aged 6-12 months with low nutritional status, whereas the comparison are infants aged 6-12 months with normal nutritional status. The dependent variable is the nutritional status and the independent variables are breastfeeding status, mother's education level, mother's employment, mother’s knowledge of nutrition, and breastfeeding counseling status. Data analysis was performed by univariate, bivariate (Chi-Square) and multivariate (logistic regression).
Result : From the 5 (fi ve) variables were analyzed, 2 (two) variables independently became risk factor for malnutrition are status of breastfeeding (OR=6.667) and the counseling status of breastfeeding (OR=3.215). But together (simultaneously), only breastfeeding status has an infl uence on the nutritional status of infants, and non-exclusive breastfeeding was signifi cant as a risk factor for malnutrition (OR=5.126). Probability infant to experience malnutrition due to breastfeeding status no exclusive is at 25.54%.
Conclusion : Breastfeeding status has an infl uence on the nutritional status of infants and non-exclusive breastfeeding was signifi cant as a risk factor for malnutrition among infants aged 6-12 months.

Key words : breastfeeding status, nutritional status, infant, case-control

1 Korespondensi: Unit Pelaksana Teknis Daerah Puskesmas Kalampangan Kota Palangka Raya, Jl. Mahir Mahar Km 18,5, Palangka Raya, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
2 Jurusan Gizi Politeknik Kesehatan Kementerian Kesehatan Palangka Raya, Jl. George obos No. 30, Palangka Raya, e-mail: nilafado_gk@ yahoo.co.id

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Polimorfi sme gen ferroportin (FPN1) -1355 G/C sebagai faktor risiko anemia defi siensi besi pada ibu hamil

Nor Istiqomah1, Sarah Safira Umarghanies2, Arta Farmawati2, Ahmad Hamim Sadewa2, Yuliana Heri Soesilo3, Kusumadewi Eka Damayanti3, Dono Indarto3

ABSTRACT

According to WHO data, prevalence of anemia pregnancy in Indonesia is 44.3%, it’s higher than world prevalence (41.8%). Ferroportin (FPN1) is one of important iron exsporter for iron absorption, release, and recycle inside the body. The varian of FPN1-1355 G/C in promoter region, leads to increased of ferroportin expression and iron export, increased cellular iron needs, overexpression of soluble transferrin receptor (sTfR), decrease hemoglobin (Hb) and erythrocyte indices that manifest to iron defi ciency anemia (IDA).
Objective : This research will study the frequency of FPN1-1355 G/C polymorphism as a risk factor of IDA in pregnant women in Indonesia.
Method : The research design was a case and control study. Blood samples were taken from 26 pregnant women with anemia and 48 pregnant women without anemia. FPN1-1355G/C polymorphism were determined using PCR-RFLP method. sTfR and ferritin level were measured with ELISA. Hemoglobin, erythrocyte indices, and sTfR level were compared among genotype group, then statistically analyzed using independent sample t-test and one way ANOVA. Bivariat analysis of Pearson test was conducted to analyze correlation between level of blood Hb and ferritin in pregnant women (p<0.05).
Result : FPN1-1355 G/C polymorphism with frequency in pregnant women with IDA and in pregnant women with anemia non IDA were 100% and 95.2%, respectively (p=0.710; OR=1.600; 95%CI: 0.296-8.653). The mean of Hb level and erythrocyte indices in subjects carrying C allele were lower than subjects carrying only G allele although Hb level is not signifi cantly different (p>0.05). The sTfR and hepcidin level in subjects carrying C allele were higher than subjects carrying only G allele (p<0.05).
Conclusion : In this study the FPN1 gene promoter -1355 G/C polymorphism was not a risk factor for anemia, but it was a risk factor for iron defi ciency anemia in pregnant women.

Key words: polymorphism of ferroportin (FPN1) -1355 G/C, iron defi ciency anemia (IDA), soluble transferin receptor (sTfR), ferritin

1 Korespondensi: Program Studi Kesehatan Masyarakat, Fakultas Ilmu Kesehatan Universitas Pekalongan, Jl. Sriwijaya no 3, Pekalongan, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
2 Bagian Biokimia, Fakultas Kedokteran Universitas Gadjah Mada, Jl. Farmako, Sekip Utara, Yogyakarta, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
3 Fakultas Kedokteran Universitas Sebelas Maret, Jl. Ir. Sutami No. 36 A Kentingan, Jebres, Surakarta 57126

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Hipoalbuminemia praoperasi pasien kanker kolorektal terhadap risiko komplikasi pascaoperasi dan lama rawat inap

Yohanes Benny1, Teguh Aryandono2, Susetyowati2

ABSTRACT

Background
: Malnutrition is most commonly found in gastrointestinal cancer that affects the result of operation. Albumin serum is an effective and simple way of assessing risk which is associated with malnutrition intensity so that it is generally used as prognostic index for the development of the incidence of colorectal cancer postoperative complications.
Objective : To identify effect of preoperative hypoalbumin to the incidence of postoperative complications and length of stay of colorectal cancer inpatients.
Method : The study used quantitative approach with non concurrent cohort (retrospective analysis) design. Population were patients diagnosed having colorectal cancer who would undergo operation at Kasih Ibu, Dr. Oen, and Panti Waluyo Hospital of Surakarta. Data analysis used Chi-Square test and logistic regression.
Result : Hypoalbumin, either based on admission or pre operation, was signifi cant risk factor for the incidence of post operative complications in colorectal cancer patients as well as age and American Society of Anesthesiologist Physical Status Classifi cation (ASA) status. The result of multivariate analysis showed age of 20-59 years (OR=2), hypoalbumin based on admission (2.1 times) and preoperation (1.9 times) were risk factors for the incidence of postoperative complication (infection). ASA status III-IV had risk 2.8 times for the incidence of postoperative sepsis complications and 3.7 times for mortality than ASA status I-II. Status of hypoalbumin did not infl uence total length of stay or postoperative length of stay but age infl uenced postoperative length of stay.
Conclusion : Hypoalbumin infl uenced the incidence of postoperative complications in colorectal cancer patients, particularly infection complication; whereas factors of age and ASA status were external factors strongly infl uenced. Hypoalbumin did not infl uence length of stay. Age was external factor that strongly infl uenced postoperative length of stay.

Key words : hypoalbumin, postoperative complications, length of stay, age, ASA status, cancer

1 Korespondensi: Rumah Sakit Kasih Ibu Surakarta, Jl. Slamet Riyadi 404, Laweyan, Surakarta
2 Fakultas Kedokteran Universitas Gadjah Mada, Jl. Farmako, Sekip Utara, Yogyakarta 55281
3 Program Studi Gizi Kesehatan, Fakultas Kedokteran Universitas Gadjah Mada, Jl. Farmako, Sekip Utara, Yogyakarta 55281, e-mail: susetyowati2000@ yahoo.com

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Asupan makan, sindrom metabolik, dan status keseimbangan asam-basa pada lansia

Nurmasari Widyastuti1, Muhammad Sulchan1, Andrew Johan2

ABSTRACT

Background
: Metabolic syndrome prevalence increases with age and obesity. The metabolic syndrome is associated with alterations in renal function. Low urine pH has been described as a renal manifestation of the metabolic syndrome. Urine pH is a simple and inexpensive method for determining acid-base status. Recent studies suggest that acid-base status is associated with dietary intake.
Objective : To examine relationship between dietary intake, components of metabolic syndrome and urine pH among the elderly.
Methods : Subjects of this cross-sectional study consist of 49 elderly that were collected consecutively. Height, weight, waist circumference (WC), dietary intake, blood pressure (BP), fasting blood glucose and urine were obtained. Rank Spearman correlation test was used to examine the correlation of components of metabolic syndrome and dietary intake with urine pH. Mann-Whitney test was used to compare the urine pH of the metabolic syndrome group and the normal group. Chi-Square/fi sher test was used to calculate prevalence ratio (PR) of metabolic syndrome components to low urine pH. Multivariate analysis was done by multiple linear regression.
Result : The mean urine pH of the metabolic syndrome group was 6,06 and signifi cantly lower than the normal group (6,50). WC was the only component of metabolic syndrome that related to urine pH (r=-0,325; p=0,023). Abdominal obesity signifi cantly increases the risk of low urine pH (RP=1,6; p=0,023; CI=1,005-2,442). Urine pH was negatively associated with protein intake and proportion of protein on diet. In multivariate analysis, WC is the most signifi cant factor that predicted urinary pH.
Conclusion : Urine acidifi cation is a characteristic of abdominal obesity and the metabolic syndrome. Protein intake and proportion of protein on diet contribute to urine pH.

Key words : metabolic syndrome, abdominal obesity, low urine pH, protein intake

1 Korespondensi: Program Studi S1 Ilmu Gizi, Fakultas Kedokteran Universitas Diponegoro, Jl. Dr. Sutomo No. 18, Semarang, e-mail: widy astuti This e-mail address is being protected from spambots. You need JavaScript enabled to view it
2 Bagian Biokimia, Fakultas Kedokteran Universitas Diponegoro, Jl. Prof. Sudharto, SH, Tembalang, Semarang

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Status kesehatan mulut dan asupan makan sebagai faktor risiko underweight pada lansia

Dian Isti Angraini1, Al Supartinah2, Deddy Nur Wachid3

ABSTRACT

Background
: Oral health status and dietary intake contribute to nutritional status in elderly. Missing teeth cause chewing disorder that reduces quality and quantity of food intake, which fi nally makes the elderly have underweight nutritional status.
Objectives : To determine the risk factors for underweight in the elderly at Yogyakarta Municipality
Methods : The study was observational with case control design on elderly at Yogyakarta Municipality. Subjects consisted of 210 elderly matched in age and gender. Sampling was done by multistage random sampling. Oral health status was assessed through dental health status (index of missing teeth) and periodontal status (gingival index, periodontal index and oral hygiene index), dietary intake was collected by using semi quantitative food frequency questionnaire (SQ-FFQ) and underweight nutritional status was based on body mass armspan (BMA). Data were analyzed by using tests of X2 Mc.Nemar, X2 Stuart Maxwell, and conditional logistic regression.
Results : Bivariate analysis showed the number of missing teeth > 21 (OR=3.67, p<0.05) and 16-20 (OR=3.53, p<0.05) as risk factors of underweight, whereas the gingival index, periodontal index and oral hygiene index were not. Less intake of energy (OR=6.3), protein (OR=7.83), fat (OR=5.67) and carbohydrates (OR=7.5) were risk factors of underweight (p<0.01). Income less than Rp 808.000,00 was also risk factor for underweight (OR=4.5; p<0.01). Multivariate analysis showed the signifi cant risk factors for underweight were the missing teeth > 21 (OR=8.76) and 16-20 (OR=6.04) which increased by income less than Rp 808.000,00 (OR=5.94), less fat intake (OR=4.88), and less carbohydrate intake (OR=5.48). Income was confounding factor in the risk of missing teeth and protein intake for becoming underweight.
Conclusion : Signifi cant risk factors of underweight in elderly were missing teeth > 16, less intake of fat and carbohydrate, and income less than Rp 808.000,00.

Key words elderly, underweight, oral health status, dietary intake

1 Korespondensi: Program Studi Gizi Kesehatan, Fakultas Kedokteran Universitas Lampung, Jl. Prof. Dr. Sumantri Brojonegoro No. 1 Bandar Lampung, 35145, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
2 Bagian Kedokteran Gigi Anak, Fakultas Kedokteran Gigi Universitas Gadjah Mada, Jl. Bulak Sumur, Yogyakarta 55281
3 Bagian Penyakit Dalam, Rumah Sakit Umum Pusat Dr. Sardjito, Jl. Kesehatan No.1, Yogyakarta

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Perubahan parameter biologik jaringan kanker payudara mencit akibat pemberian isoflavon tempe

Siti Harnina Bintari1, Siti Fatimah Moeis2, Sarjadi2

ABSTRACT

Background
: Cancer is severe diseases caused by the changing of deoxyribonucleic acid (DNA) structure. Women who consume soy products have a lower risk for breast cancer, but it cannot be explained the kind of biomolecular aspects of soy product which gives this role.
Objectives : The aim of this research was to analyze the biological parameter changing of AgNORs, p53, Cas-3 and Bcl-2 in mouse (Mus musculus) C3H strain with breast cancer, as the impact of injecting isoflavone of tempeh.
Methods : The laboratory experimental research was done by posttest only randomized controlled group design. Subject of study were 18 mice (Mus musculus) C3H strain that were divided into 3 groups, each of which consists of 6 mice. The first group, the control (K), was not injected by isoflavone, while the second group (P1) and the third group (P2) were injected by 1.000 mg and 10.000 mg of tempeh isoflavone/kg diet/day, respectively. All groups were given the transplanted breast cancer cells. AgNORs parameters were selected to determine the level of proliferation and p53 parameters, Cas-3 and Bcl-2 to determine the appearance of apoptosis. Data were analyzed by using Manova and discriminant test for each parameter of cell proliferation.
Results : Concentration of isoflavones supplementation with 1,000 and 10,000 mg / kgdiet / day gave effect to the reduction in AgNORs blots, expression of p53 and Cas-3 and increased expression of Bcl-2 in group P1 and P2 compared with control group, as indicated by high statistical values (p = 0.000) between both groups or within the group. Results of discriminant test showed that Bcl-2 and AgNORs had dominant role in increased apoptosis and inhibition of cancer cell proliferation in experimental animal.
Conclusion : Tempeh isoflavones can be used as a biological parameter change agent that marks the proliferation and apoptosis of mice (Mus musculus) C3H strain towards the normal cell cycle progression.

Key words : AgNORs, p53, Cas-3, Bcl-2, breast cancer, tempeh isoflavones

1 Universitas Negeri Semarang, Jl. Raya Sekaran, Gunung Pati, Semarang, Telp. (024) 8508033, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
2 Bagian Gizi Klinik, Program Pendidikan Dokter Spesialis, Fakultas Kedokteran Universitas Diponegoro, Jl. Dokter Sutomo No 18, Semarang 50231, Telp. (024) 7460013, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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