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Jurnal Vol.8, No.3

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ARTIKEL - Januari 2012, Vol.8, No.3

Pengaruh propolis terhadap profil lipid plasma tikus model hiperkolesterolemia

Diah Krisnansari1, Ariadne Tiara Hapsari1, Evy Sulistyoningrum1, Agus Prastowo2

ABSTRACT

Background
: Nowadays, cardiovascular disease caused by hypercholesterolemia has become the main cause of death. Propolis has been used widely to reduce plasma cholesterol levels.
Objective : The aims of this research was to study the effect of propolis on lipid profile of hypercholesterolemic Sprague Dawley rats.
Method : This was an experimental study with pre-post test. Twenty four (24) male Sprague Dawley rats aged 12-16 weeks, weighing 125-200 g were allocated into 4 groups. Group I received standard meal + aquadest-gavage; group II received high cholesterol meal + PTU 0,01 + aquadest gavage; group III received high cholesterol meal + PTU 0,01 + 0,027 g propolis gavage; group IV received high cholesterol meal + PTU 0,01 + 0,054 g propolis gavage. Total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol levels before and after treatment were measured. The data were then analyzed with One Way Anova.
Result : The study showed that there were no significant differences in changes of body weight. There were significant differences in total cholesterol levels between all groups of treatment. Triglyceride levels were significantly different among all groups, except between group I and IV. Furthermore, the HDL cholesterol levels of group I vs III and group I vs IV were significantly different. However, there were no differences found in LDL cholesterol levels among all groups of treatment.
Conclusion : Provision of 0,027 g and 0,054 g propolis improve lipid profile (total cholesterol, triglyceride and HDL cholesterol levels) of hypercholesterolemic rats.

Key words : total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol, propolis

1 Jurusan Kedokteran Fakultas Kedokteran dan Ilmu-Ilmu Kesehatan, Universitas Jenderal Soedirman, Kampus FKIK Unsoed Berkoh, Jl. Dr. Gumbreg/Jl. Medika, Purwokerto, Jawa Tengah, Telp/Fax (0281) 622022, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
2 Instalasi Gizi Rumah Sakit Prof. Dr. Margono Soekarjo, Jl. Dr. Gumbreg No. 1 Purwokerto, Jawa Tengah, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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Obesitas sentral berhubungan dengan toleransi glukosa terganggu pada remaja perempuan

Lucia Mawarti Dwi Astuti1, Endy Paryanto Prawirohartono1, Noormanto1, Madarina Julia1

ABSTRACT

Background
: Obesity in adolescents has become health problem in Indonesia. Central obesity is associated with insulin resistance.Theoretically, insulin resistance will cause impaired glucose tolerance (IGT) and could develop into type 2 diabetes.
Objective : The aim of this study were to evaluate the difference in IGT prevalence between central and non central obesity and to identify the risk factors associated with IGT.
Method : A cross sectional study was conducted at 3 private secondary schools in Yogyakarta and recruited 62 obese female students aged 12-18 years.The subjects were classified into central obesity (BMI/U> +2SD and waist circumference > p90) and non central obesity based on anthropometric data. Fasting glucose and 2 hours after loading were measured in all subjects. Differences in the proportion of IGT between the two groups was calculated by Chi-square test and risk factors associated with IGT were calculated by multivariate logistic regression with 95% confidence interval.
Result : Of 62 subjects, 14 of them have IGT and the prevalence of IGT was significantly higher in the central obesity group compared to non central obesity group (11/31 vs 3/31, p=0.03). Central obesity was found to be the only risk factor of IGT (OR=4.6; 95%CI: 1.04 to 20.24). Twenty one of the subjects were found to have impaired fasting glucose (IFG) (34%) and one subject (1.6 %) had IFG+IGT. There were no differences in the proportion of IFG between central and non central obesity groups.
Conclusion : The prevalence of IGT in female students with central obesity was higher compared to those with non central obesity. A female student with central obesity had 4.6-fold risk of having IGT compared to those with non central obesity.

Key words : central obesity, impaired glucose tolerance, female student, prevalence, cross sectional study, impaired fasting glucose

1 Bagian Anak Rumah Sakit Umum Pusat Dr. Sardjito/Fakultas Kedokteran Universitas Gadjah Mada, Jl.Kesehatan No 1 Yogyakarta 55281, Telp (0274) 561616, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it *, This e-mail address is being protected from spambots. You need JavaScript enabled to view it , This e-mail address is being protected from spambots. You need JavaScript enabled to view it
*correspondence author

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Pengendalian Superoxide Dismutase (SOD) dan Nitrit Oxide(NO) pada penderita DMT2 dengan emping garut (Maranta arundinacea Linn) sebagai makanan selingan

Betty Prastuti1, Sunarti2

ABSTRACT

Background
: Hyperglycemia in diabetes mellitus increases the production of superoxide that cause oxidative stress and decrease the activity of superoxide dismutase (SOD). SOD enzyme reduces superoxide to hydrogen peroxide to lessen the reaction between superoxide and nitric oxide (NO). To reduce hyperglycemia in diabetes mellitus, diabetics are encouraged to consume diet with low glycemic index. Arrowroot chips is a product commonly used by the community as a snack. Arrowroot has low glycemic index (glycemic index = 14) so it can be used as an alternative snack for diabetics.
Objective : The aim of this study is to determine the beneficial effects of arrowroot chips to help controlling the blood glucose level, SOD activity and NO concentration in type 2 diabetes.
Method : This is a quasi-experimental research with a one group pre test - post test. Subjects were 14 patients with type 2 diabetes mellitus who regularly visited endocrine polyclinic of RSUP.Dr. Sardjito Yogyakarta. The inclusion criteria were: aged 35-60 years, had suffered from diabetes mellitus for at least one year and currently on insulin injection therapy. The subjects were given 20 grams/day arrowroot chips to be consumed as a snack for four weeks. The blood samples were drawn before and after treatment. Glucose level were analyzed by GOD-PAP method, SOD activity was determined by Ransod kits and NO concentration was analyzed by colorimetric Gies reagent system. Finally, data were analyzed by paired t-test and correlation regression test.
Result : There was an increased glucose level from 124,43 ± 33,56 to 139,00 ± 67,96 mg/dl after treatment (p=0,551), SOD activity decreased from 77,09 + 19,33 to 43,99 + 17,45 unit/ml whole blood after treatment (p=0,000), decreased NO concentration from 1,28 + 1,32 to 1,15 + 0,577 µM after treatment (p=0,875), and a positive correlation between SOD activity and NO concentration (p=0,151; r=0,405; R2=0,164).
Conclusion : Arrowroot chips consumption as a snack for 4 weeks was unable to help controlling the fasting plasma glucose level, SOD activity and NO concentration in type 2 diabetics.

Key words: hyperglycemia, arrowroot chips, fasting plasma glucose, SOD, NO, DM

1 Universitas Respati Yogyakarta, Progam Studi Ilmu Gizi Fakultas Ilmu Kesehatan, Jl. Laksda Adisucipto Km 6,3 Depok, Sleman, Yogyakarta, Telp(0274) 3151363, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
2 Bagian Biokimia Fakultas Kedokteran Universitas Gadajah Mada, Jl Farmako, Sekip Utara, Yogyakarta 55281, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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Citra tubuh, asupan makan, dan status gizi wanita usia subur pranikah

Yhona Paratmanitya1, Hamam Hadi2, Susetyowati3

ABSTRACT

Background
: Premarital reproductive age women are prospective mothers whose nutritional status should be monitored, because it can affect the outcome of pregnancy. Premarital period can be interpreted as pre conception period. As the wedding ceremony approaches, women’s concern of their body image is increasing. Negative body image can influence their dietary intake and nutritional status. Research on the effect of pre wedding body image on women’s dietary intake and nutritional status in non-western countries is still limited.
Objective : The aim of this research was to describe the relationship between body image, dietary intake and nutritional status of premarital reproductive age women in Yogyakarta city.
Method : This research was an observational research with cross-sectional design. The subjects were 157 premarital reproductive age women in Yogyakarta city who came to the office of religious affairs to register their marriage or followed the premarital advisory program. Body image was measured by Body Shape Questionnaire (BSQ-34); dietary intake was measured by Semi-Quantitative Food Frequency Questionnaire (SQFFQ); and nutritional status was classified based on Body Mass Index (BMI). Data were analyzed with Chi-Square test, t-test and multiple logistic regression.
Result : Only 12,1% of participant reported dissatisfied of their body image. Dominant factor that affect their body image was environmental influence (OR=14,5). Bivariat analysis showed that there was a significant relationship between body image and nutritional status (p<0,05; OR=15,6), as well as dietary intake and nutritional status (p<0,05). However, body image and dietary intake was not significantly associated (p>0,05). Multiple logistic regression analysis showed that factors associated with nutritional status were body image, carbohydrate intake and environmental influence.
Conclusion : Body image was associated with nutritional status. However, body image does not affect dietary intake. Energy, protein, fat and carbohydrate intake were significantly associated with nutritional status.

Key words : premarital reproductive age women, body image, dietary intake, nutritional status

1 Sekolah Tinggi Ilmu Kesehatan Alma Ata Yogyakarta. Jl. Ringroad Barat Daya No. 1, Tamantirto, Yogyakarta, Telp (0274) 4342288, 4342270 e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
2 Magister Gizi dan Kesehatan Fakultas Kedokteran Universitas Gadjah Mada, Jl. Farmako, Sekip Utara Yogyakarta 55281, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
3 Program Studi Gizi Kesehatan Fakultas Kedokteran Universitas Gadjah Mada, Jl. Farmako, Sekip Utara Yogyakarta 55281, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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Pengetahuan dan sikap orang tua hubungannya dengan pola konsumsi dan status gizi anak autis

Maria Martiani1, Elisabeth Siti Herini2, Martalena Br Purba3

ABSTRACT

Background
: The prevalence of autistic spectrum disorder (ASD) has increased in recent years. In 1993 the prevalence of ASD was 2-4 cases per 10.000 children. The number increased significantly to 152 cases per 10.000 children in 2003 (0.15-0.2%). In addition to diet, nutritional status can be influenced by parent’s knowledge and attitudess toward children with autism. Improving parent’s knowledge and attitudess about autism can be an effective way to manage children with autism.
Objective : To examine the relationship between parent’s knowledge and attitudes toward autism with dietary pattern and nutritional status of autistic children in SLBN Semarang.
Methods : This was an observational study with cross sectional design. The subjects were students with autism who attended SLBN Semarang and their parents. A questionaire was used to collect the information on parent’s knowledge and attitudes toward autism, Food Frequency Questionnaire (FFQ) was used to obtain the data on gluten and casein consumption, whereas the data on nutritional status were measured by weight and height of the children. Chi square and Fisher Exact test were used to analyze the data.
Result : As many as 55.3% of parents have good knowledge and 65.8% have a possitive attitudes toward autism. Fifty percent of children presented with good consumption pattern of gluten, 65% exhibited good consumption pattern of casein and 55.3% of autistic children had good consumption pattern of both gluten and casein. Almost half (47.4%) of the children were undernourished. There were no association found between parent’s knowledge and gluten and casein consumption (p>0.05); parent’s knowledge and nutritional status (p>0.05); and parent’s attitudes and nutritional status (p>0.05). Only parent’s attitudes towards autism was found to be associated with casein and gluten consumption pattern (p<0.05).
Conclusion : There was a significant association between parent’s attitudes and consumption of gluten and casein in children with autism.

Key words : autism, knowledge, attitudes, food consumption, nutritional status, casein, gluten

1 Perum Tanah Mas, Jl. Pasir Mas III No. 51, Semarang 50177, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
2 Instalasi Kesehatan Anak Rumah Sakit Umum Pusat Dr. Sardjito, Jl. Kesehatan No. 1, Yogyakarta 55281, Telp (0274) 561616, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
3 Instalasi Gizi Rumah Sakit Umum Pusat Dr. Sardjito, Jl. Kesehatan No. 1, Yogyakarta 55281, Telp (0274) 587333, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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Status gizi berhubungan positif dengan derajat nyeri sendi penderita osteoartritis lutut

Nyoman Kertia1

ABSTRACT

Background
: Knee osteoarthritis (OA) is a common disorder that is associated with significant morbidity, disability, and medical costs, particularly in its advanced stages. While the cause of knee OA remains unclear, it has been associated with various risk factors, such as age, sex, genetic predisposition, biomechanical, and obesity. Pain in osteoarthritis occurs due to combination of various factors. Pain significantly increases the medical and non medical cost in OA. Data showed that obesity will increase the mechanical stress and pain of knee OA. However, uncertainty remains regarding potential relationship between body mass index (BMI) and pain in osteoarthritis. Moreover, since obesity is one of modifiable and preventable risk factors for the onset and progression of the disease, it is important to know the correlation between BMI and severity of pain in knee OA.
Objectives : To investigate the relationship between body mass index and severity of joint pain in knee osteoarthritis.
Methods : A cross sectional study was conducted and subjects were osteoarthritis patients in rheumatology clinic of Sardjito general hospital. Body mass index and visual analogue scale (VAS) score were measured. Correlation between BMI and VAS score were analyzed by bivariate correlation test.
Results : There were 80 patients with osteoarthritis who participated in the study. Mean BMI was 26.36 +4.23 kg/m2 and VAS score was 52.40+24.53 mm. The correlation test showed that there was a positive but non significant correlation between BMI and VAS scores (r = 0,11; p = 0,33).
Conclusion : There was a positive but non significant correlation between body mass index and the severity of joint pain in knee osteoarthritis.

Key words : conventional nutrition care, medical nutrition therapy, length of stay

1 Sub Bagian Reumatologi, Bagian Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Gadjah Mada/ Rumah Sakit Umum Pusat Dr. Sardjito, Jl. Kesehatan No.1, Yogyakarta 55281, Telp (0274) 553119, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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Status kesehatan oral dan asupan zat gizi berhubungan dengan status gizi lansia

Akhdrisa Mura Wijaya1, I Dewa Putu Pramantara2, Retno Pangastuti3

ABSTRACT

Background
: Central Bureau of Statistics data in 2006, showed that the average life expectancy of the population living in Yogyakarta (DIY) was 73 years, and 73.8 years for those living in Sleman. This was higher than the average national life expectancy of 68.5 years. National Health Survey in 2007 showed that the prevalence of oral and dental problems in DIY was 23.6%, while the pulp and periapical tissue diseases in the elderly in Sleman districts was approximately 1704 cases. Hence, it was classified as one of the 10 most prevalent diseases in Public Health Centre. In addition, there were 406 older adults who were underweight.
Objectives : To investigate the relationship between oral health status, nutrient intake and nutritional status in older adults.
Methods : This study is an observational study with cross sectional design. Subjects were 310 patients aged 60-74 years old in Sleman district. Data obtained by interview, examination of the oral health status, measurement of body weight and arm span. Data were analyzed with Chi-square test.
Results : There was a significant association between oral health status and protein intake (RP=2.38; 95%CI:1.42-3.970). Energy, fat and carbohydrates intake were not associated with oral health status (p>0,05). Nutritional status was significantly associated with the intake of the energy (RP=2.98, 95%CI:1.58-5.58), protein (RP=2.44, 95%CI:1,05-5.67), fat (RP=3.68, 95%CI:1.93-7.03) and carbohydrates (RP=4.89, 95%CI:2.54-9.4). However, there were no relationship found between oral health and nutritional status (RP=1.79, 95%CI:0.94-3.43.)
Conclusion : There was a significant association between oral health status and protein intake. The intake of nutrients (energy, protein, fat, and carbohydrate) was significantly associated with nutritional status. However, there was no significant relationship found between oral health and nutritional status in older adults.

Key words : oral health status, nutrient intake, nutritional status, elderly

1 Instalasi Gizi Rumah Sakit Umum Daerah Siti Aisyah, Jl.Letkol Sukirno No. 20A Lubuklinggau Sumatera Selatan, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
2 Bagian Penyakit Dalam Rumah Sakit Umum Pusat Dr. Sardjito, Jl. Kesehatan No 1, Yogyakarta 55281, Telp (0274) 587333-397
3 Instalasi Gizi Rumah Sakit Umum Pusat Dr. Sardjito, Jl. Kesehatan No 1, Yogyakarta 55281, Telp (0274) 7102931

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